Skip to main content
. 2019 Nov 11;176(Suppl 1):S142–S228. doi: 10.1111/bph.14749
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=538 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=539 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=540 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=541 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=542 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=543 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=544
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6218, http://www.uniprot.org/uniprot/Q09470 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6220, http://www.uniprot.org/uniprot/P16389 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6221, http://www.uniprot.org/uniprot/P22001 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6222, http://www.uniprot.org/uniprot/P22459 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6224, http://www.uniprot.org/uniprot/P22460 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6225, http://www.uniprot.org/uniprot/P17658 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6226, http://www.uniprot.org/uniprot/Q96RP8
Associated subunits Kv1.2, Kv1.4, Kvβ1 and Kvβ2 [http://www.ncbi.nlm.nih.gov/pubmed/10428084?dopt=AbstractPlus] Kv1.1, Kv1.4, Kv β1 and Kv β2 [http://www.ncbi.nlm.nih.gov/pubmed/10428084?dopt=AbstractPlus] Kv1.1, Kv1.2, Kv1.4, Kv1.6, Kv β1 and Kv β2 [http://www.ncbi.nlm.nih.gov/pubmed/10428084?dopt=AbstractPlus] Kv1.1, Kv1.2, Kvβ1 and Kvβ2 [http://www.ncbi.nlm.nih.gov/pubmed/10428084?dopt=AbstractPlus] Kv β1 and Kv β2 Kv β1 and Kv β2 Kv β1 and Kv β2
Channel blockers http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2563 (pEC50 7.7–9) [http://www.ncbi.nlm.nih.gov/pubmed/7517498?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/1921987?dopt=AbstractPlus] – Rat, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2547 (Inhibition) (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/24878374?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2343 (Inhibition) (pK d 3.5) [http://www.ncbi.nlm.nih.gov/pubmed/7517498?dopt=AbstractPlus] – Mouse http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2547 (Inhibition) (pIC50 11.2) [http://www.ncbi.nlm.nih.gov/pubmed/24878374?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2563 (pIC50 7.8–9.4) [http://www.ncbi.nlm.nih.gov/pubmed/7517498?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/1921987?dopt=AbstractPlus] – Rat, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2552 (pK d 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/7517498?dopt=AbstractPlus] – Rat http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2547 (pIC50 10–10.3) [http://www.ncbi.nlm.nih.gov/pubmed/8360176?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/10961988?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2552 (pK d 9) [http://www.ncbi.nlm.nih.gov/pubmed/7517498?dopt=AbstractPlus] – Mouse, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2332 (pIC50 6.8) [http://www.ncbi.nlm.nih.gov/pubmed/9792177?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2343 (pK d 2) [http://www.ncbi.nlm.nih.gov/pubmed/7517498?dopt=AbstractPlus] – Mouse http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2416 (pIC50 1.9) [http://www.ncbi.nlm.nih.gov/pubmed/2555158?dopt=AbstractPlus] – Rat http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2416 (pIC50 4.3) [http://www.ncbi.nlm.nih.gov/pubmed/8508531?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2563 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/2347305?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2343 (pIC50 2.2) [http://www.ncbi.nlm.nih.gov/pubmed/2347305?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2552 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/9488722?dopt=AbstractPlus] – Mouse, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2416 (pIC50 3.6) [http://www.ncbi.nlm.nih.gov/pubmed/9488722?dopt=AbstractPlus] – Mouse
Selective channel blockers – – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2555 (pIC50 7.1) [http://www.ncbi.nlm.nih.gov/pubmed/10213593?dopt=AbstractPlus] – – – –
Functional Characteristics KV KV KV KA Kv KV KV
Comments – – Resistant to dendrotoxins Resistant to dendrotoxins Resistant to external TEA – –