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. 2019 Nov 11;176(Suppl 1):S142–S228. doi: 10.1111/bph.14749
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=560 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=561 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=562 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=563 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=564
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6294, http://www.uniprot.org/uniprot/P51787 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6296, http://www.uniprot.org/uniprot/O43526 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6297, http://www.uniprot.org/uniprot/O43525 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6298, http://www.uniprot.org/uniprot/P56696 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6299, http://www.uniprot.org/uniprot/Q9NR82
Activators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2601 (pEC50 5.6) [http://www.ncbi.nlm.nih.gov/pubmed/11466425?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5483 (pEC50 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/30021858?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2601 (pEC50 6.2) [http://www.ncbi.nlm.nih.gov/pubmed/11466425?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2601 (pEC50 5.2) [http://www.ncbi.nlm.nih.gov/pubmed/11466425?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2601 (pEC50 5) [http://www.ncbi.nlm.nih.gov/pubmed/11890900?dopt=AbstractPlus]
Selective activators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5483 (pEC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/30021858?dopt=AbstractPlus]
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2596 (pK d 6.1) [http://www.ncbi.nlm.nih.gov/pubmed/10825393?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2599 (pIC50 4.4) [http://www.ncbi.nlm.nih.gov/pubmed/12690036?dopt=AbstractPlus] – Mouse http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2596 (pIC50 6.2) [http://www.ncbi.nlm.nih.gov/pubmed/9836639?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2599 (pIC50 5.3) [http://www.ncbi.nlm.nih.gov/pubmed/9836639?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2599 (pIC50 5.4) [http://www.ncbi.nlm.nih.gov/pubmed/9836639?dopt=AbstractPlus] – Rat http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2596 (pIC50 5.3) [http://www.ncbi.nlm.nih.gov/pubmed/11245603?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2599 (pIC50 4.9) [http://www.ncbi.nlm.nih.gov/pubmed/11245603?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2599 (pK d 4.8) [http://www.ncbi.nlm.nih.gov/pubmed/10787416?dopt=AbstractPlus]
Sub/family‐selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2596 (pIC50 4.2) [http://www.ncbi.nlm.nih.gov/pubmed/10816588?dopt=AbstractPlus]
Channel blockers http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2343 (pIC50 3.5–3.9) [http://www.ncbi.nlm.nih.gov/pubmed/10711337?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/10953053?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2343 (pIC50 1.3) [http://www.ncbi.nlm.nih.gov/pubmed/18786918?dopt=AbstractPlus]
Functional Characteristics cardiac IK5 M current as a heteromer between KV7.2 and KV7.3 M current as heteromeric KV7.2/KV7.3 or KV7.3/KV7.5 M current as heteromeric KV7.3/KV7.5