Nomenclature | http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=746 |
HGNC, UniProt | https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:28240, http://www.uniprot.org/uniprot/Q96D96 |
Channel blockers | http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=566 (pIC50 ∼5.7–6.3), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2440 (pIC50 ∼5) |
Functional Characteristics | Activated by membrane depolarization mediating macroscopic currents with time‐, voltage‐ and pH‐dependence; outwardly rectifying; voltage dependent kinetics with relatively slow current activation sensitive to extracellular pH and temperature, relatively fast deactivation; voltage threshold for current activation determined by pH gradient (ΔpH = pHo ‐pHi) across the membrane |