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. 2019 Nov 11;176(Suppl 1):S142–S228. doi: 10.1111/bph.14749
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=746
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:28240, http://www.uniprot.org/uniprot/Q96D96
Channel blockers http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=566 (pIC50 ∼5.7–6.3), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2440 (pIC50 ∼5)
Functional Characteristics Activated by membrane depolarization mediating macroscopic currents with time‐, voltage‐ and pH‐dependence; outwardly rectifying; voltage dependent kinetics with relatively slow current activation sensitive to extracellular pH and temperature, relatively fast deactivation; voltage threshold for current activation determined by pH gradient (ΔpH = pHo ‐pHi) across the membrane