. 2019 Dec 1;10(6):1270–1281. doi: 10.14336/AD.2019.0216

Table 3.

Cox proportional hazard regression with primary and secondary outcomes.

Outcomes	Event	PY	ID^*	Crude		Model 1^%		Model 2^#		Model 3^&		Competing risk
Outcomes	Event	PY	ID^*	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
*Entering chronic dialysis*

Frailty component count

0	4,107	479,967.2	8.6	1	-	1	-	1	-	1	-	1	-
1	2,261	165,463.9	13.7	1.57	1.49-1.65^a	1.13	1.06-1.2^b	1.14	1.07-1.22^a	1.14	1.07-1.22^a	1.09	1.03-1.16^b
2	535	29,994.1	17.8	2	1.82-2.19^a	1.18	1.06-1.3^b	1.2	1.09-1.34^b	1.2	1.08-1.33^b	1.07	0.96-1.19
≥ 3	56	2,686.8	20.8	2.27	1.74-2.95^a	1.2	0.91-1.57	1.22	0.93-1.6	1.2	0.91-1.57	0.97	0.72-1.31
Every 1 component				1.44	1.4-1.49^a	1.09	1.05-1.14^a	1.1	1.06-1.15^a	1.1	1.05-1.15^a	1.04	0.99-1.09

*Mortality*
FRAIL component count
0	12,583	487,396.9	25.8	1	-	1	-	1	-	1	-
1	13,032	168,415.5	77.4	2.9	2.83-2.97^a	1.25	1.21-1.29^a	1.26	1.22-1.3^a	1.26	1.22-1.3^a
2	4,330	30,562.4	141.7	5.09	4.92-5.27^a	1.41	1.35-1.47^a	1.42	1.36-1.48^a	1.42	1.36-1.48^a
≥ 3	661	2,729	242.2	8.19	4.57-8.86^a	1.34	1.23-1.46^a	1.35	1.24-1.47^a	1.35	1.24-1.47^a
Every 1 component				2.24	2.21-2.27^a	1.16	1.14-1.18^a	1.16	1.14-1.19^a	1.16	1.14-1.19^a

*Cardiovascular events*

FRAIL component count

0	11,582	459,723	25.2	1	-	1	-	1	-	1	-
1	10,974	144,045.6	76.2	2.9	2.83-2.98^a	1.4	1.35-1.44^a	1.41	1.36-1.45^a	1.41	1.36-1.45^a
2	3,074	24,222.2	126.9	4.61	4.43-4.8^a	1.48	1.41-1.55^a	1.49	1.43-1.57^a	1.49	1.43-1.57^a
≥ 3	386	2,050.8	188.2	6.42	5.8-7.1^a	1.55	1.39-1.7^a	1.57	1.41-1.74^a	1.56	1.41-1.74^a
Every 1 component				2.18	2.15-2.21^a	1.22	1.2-1.25^a	1.23	1.2-1.25^a	1.23	1.2-1.25^a

*Hospitalization*

FRAIL component count

0	56,620	310,452.3	182.4	1	-	1	-	1	-	1	-
1	30,478	83,907.9	363.2	1.81	1.78-1.83^a	1.17	1.15-1.19^a	1.18	1.16-1.19^a	1.18	1.16-1.19^a
2	7,556	11,834.1	638.5	2.8	2.73-2.87^a	1.28	1.24-1.31^a	1.29	1.25-1.32^a	1.29	1.25-1.32^a
≥ 3	905	843.8	1072.6	4.04	3.78-4.32^a	1.36	1.27-1.46^a	1.38	1.28-1.47^a	1.38	1.28-1.47^a
Every 1 component				1.7	1.68-1.71^a	1.14	1.12-1.15^a	1.14	1.13-1.15^a	1.14	1.13-1.15^a

*ICU admission*

FRAIL component count

0	14,369	460,577.7	31.2	1	-	1	-	1	-	1	-
1	11,970	149,386.7	80.1	2.48	2.42-2.54^a	1.26	1.22-1.3^a	1.27	1.23-1.31^a	1.27	1.23-1.31^a
2	3,513	25,638.9	137	4.07	3.93-4.23^a	1.37	1.31-1.43^a	1.38	1.33-1.45^a	1.38	1.33-1.45^a
≥ 3	483	2,163.1	223.3	6.26	5.72-6.86^a	1.37	1.25-1.51^a	1.39	1.26-1.53^a	1.39	1.26-1.53^a
Every 1 component				2.05	2.02-2.08^a	1.17	1.14-1.19^a	1.17	1.15-1.19^a	1.17	1.15-1.19^a

CI, confidence interval; HR, hazard ratio; ICU, intensive care unit; ID, incidence density; PY, person-year

per 1000 patient-year

Baseline model

Baseline model, adding duration of CKD

Baseline model, adding duration of CKD and proteinuria

p < 0.001

p < 0.01