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. 2019 Dec 1;10(6):1207–1220. doi: 10.14336/AD.2018.1028

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Copyright: © 2019 Liu et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Exposure to TNFα up-regulates Ascl2 expression in neural stem cells (NSCs). (A-B) Mouse NSCs were treated with different concentrations of TNFα in proliferation (A) and differentiation (B) medium for 48 h, and Ascl2 mRNA expression levels were examined. The results were normalized to NSCs without TNFα. See also Figure S2. Pro: proliferation, Dif: differentiation. (n=3). (C-D) NSCs were treated with 20 ng/ml TNFα for various lengths of time in proliferation (C) and differentiation (D) medium, and Ascl2 mRNA expression levels were examined. The results were normalized to NSCs in differentiation medium without TNFα for 5 h. (n=3). (E-F) NSCs were treated with TNFα of different doses for 48 h in proliferation (E) and differentiation (F) medium, and the protein levels of ASCL2 were examined. Data in (A), (B), (C) and (D) are represented as the means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001 by one-way analysis of variance.