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. 2019 Oct 21;44(6):2077–2090. doi: 10.3892/ijmm.2019.4379

Figure 2.

Figure 2

SPHK1 inhibitor attenuates lung vascular hyperpermeability in the two-hit model of ventilator-associated lung injury. (A) Cell count and (B) measurements of protein concentration in BAL fluid. (C) Lung W/D was calculated as an index of pulmonary edema. (D) Pulmonary vascular permeability was determined via the analysis of Evans blue-labeled albumin extravasation into the lung tissue. Data are presented as the mean ± SEM (n=7). **P<0.01 vs. LPS or ventilated groups; #P<0.05, ##P<0.01 vs. Ventilated + LPS group. LPS, lipopolysaccharide; BAL, bronchoalveolar lavage; W/D wet-to-dry weight ratio; SPHK, sphingosine kinase.