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. 2019 Oct 29;44(6):2213–2222. doi: 10.3892/ijmm.2019.4387

Figure 2.

Figure 2

DHA reduces the inflammatory response and oxidative stress in the lungs of LPS-administered mice. Mice were treated with saline or DHA (75 mg/kg). After 1 h, mice were treated with LPS (5 mg/kg, intratracheal) or saline for 12 h. (A) IL-1β, (B) TNF-α and (C) IL-6 mRNA levels in the lungs were determined by RT-qPCR (n=6, 7). (D) IL-1β, (E) TNF-α, and (F) IL-6 protein levels in the serum were determined by ELISA (n=4-6). (G) ROS production, (H) MDA content, (I) SOD activity and (J) GSH content in lung tissue were determined (n=6-8). Data are expressed as the means ± standard error of the mean. *P<0.05, **P<0.01, ***P<0.001. DHA, dihydroartemisinin; LPS, lipopolysaccharide; ROS, reactive oxygen species; MDA, malondialdehyde; SOD, superoxide dismutase; GSH, glutathione; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.