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. 2019 Oct 11;44(6):2265–2275. doi: 10.3892/ijmm.2019.4369

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Copyright: © Zhai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Changes of TRAP-positive cell differentiation from BMMs and marker gene expression following single 2 Gy irradiation. (A) TRAP staining at 7 and 30 days after irradiation (magnification, x40). (B) Number of TRAP-positive MNCs. Expression of the cell differentiation marker genes (C) cathepsin K and (D) integrin β3. The expression levels of cathepsin K and integrin β3 were significantly upregulated at 7 days post-irradiation; however, at 30 days post-irradiation, the expression tended to return to normal levels. ^*P<0.05. TRAP, tartrate-resistant acid phosphatase; BMMs, bone marrow-derived macrophages; MNCs, mononuclear cells.