Table 2. Risks of primary and secondary outcomes.

Outcome	No. of Patients with event (%)	Crude HR (95% CI)	Crude P-value	Adjusted HR (95% CI)	Adjusted P-value
All-cause death
Low big ET-1	443 (10.6)	Reference		Reference
High big ET-1	375 (18.9)	1.69 (1.47–1.94)	< 0.001	1.38 (1.19–1.59)	< 0.001
log(big ET-1)	–	1.93 (1.55–2.40)	< 0.001	1.43 (1.13–1.80)	0.002
Cardiac death
Low big ET-1	231 (5.5)	Reference		Reference
High big ET-1	204 (10.3)	1.75 (1.44–2.11)	< 0.001	1.37 (1.13–1.67)	0.002
log(big ET-1)	–	2.11 (1.57–2.85)	< 0.001	1.53 (1.11–2.10)	0.009
MACCE
Low big ET-1	1067 (25.6)	Reference		Reference
High big ET-1	695 (35.0)	1.32 (1.20–1.45)	< 0.001	1.20 (1.09–1.32)	< 0.001
log(big ET-1)	–	1.38 (1.18–1.62)	< 0.001	1.20 (1.02–1.42)	0.027
Myocardial infarction
Low big ET-1	180 (4.3)	Reference		Reference
High big ET-1	105 (5.3)	1.13 (0.88–1.44)	0.335	1.12 (0.88–1.44)	0.358
log(big ET-1)	–	1.01 (0.69–1.48)	0.969	1.02 (0.69–1.50)	0.931
Stroke
Low big ET-1	266 (6.4)	Reference		Reference
High big ET-1	155 (7.8)	1.17 (0.96–1.43)	0.116	1.12 (0.92–1.38)	0.265
log(big ET-1)	–	1.13 (0.81–1.57)	0.469	1.06 (0.75–1.48)	0.746
Unplanned revascularization
Low big ET-1	321 (7.7)	Reference		Reference
High big ET-1	167 (8.4)	1.11 (0.92–1.34)	0.264	1.11 (0.92–1.35)	0.277
log(big ET-1)	–	1.08 (0.77–1.49)	0.663	1.12 (0.81–1.56)	0.494