Fig. 2.
Results from our analysis of lung DNA methylation data from Nicodemus-Johnson et al. (2016). (a) The number of asthma-related CpGs at a given 
-value cut-off using our shrinkage-corrected estimator (solid line), as well as the estimators proposed in Lee et al. (2017) (dot-dashed line), Wang et al. (2017) (dotted line) and Leek & Storey (2008) (dashed line). (b) The 
components of 
(
) and 
(
) as a function of 
. The dashed line is the 0.95 quantile of the 
distribution, where 
is defined such that 
converges to a chi-squared random variable with 
degrees of freedom under the null hypothesis from Theorem 3.