Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Gapped DNA recognition: conformational capture followed by an ‘on-protein’ rearrangement. Gapped DNA is dynamic adopting bent and frayed states (orange haze). Pol can bind to the upstream DNA when the downstream DNA conformation is not impeding the Pol (conformational capture of slightly bent states). Following binding of the upstream DNA, the downstream DNA now docks and is further melted, beginning the process of strand-displacement.
