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. Author manuscript; available in PMC: 2019 Nov 11.
Published in final edited form as: Expert Rev Mol Diagn. 2010 Apr;10(3):269–284. doi: 10.1586/erm.10.6

Figure 1:

Figure 1:

The cellular and molecular mechanisms underlying these histopathological hallmarks remain obscure. Immunological and non-immunological factors have been associated with the progression to chronic allograft dysfunction. Many cell-cell, cell-matrix, and intracellular pathways have been implicated in the complex pathogenesis of CAN. CAN is characterized by slowly progressive graft dysfunction ultimately leading to chronic renal failure.