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Effect of Pol II and DSIF on AID-catalyzed deamination at 5'WRC motifs within the scaffold bubble
| Strand | Mutation ratea (× 10−5) |
|---|---|
| NTS + AID | 0.6 ± 0.1 |
| NTS + Pol II + AID | 6.4 ± 2.4 |
| NTS + Pol II + AID + DSIF | 12.0 ± 0.1 |
| TS + AID | 1.4 ± 0.2 |
| TS + Pol II + AID | 9.1 ± 1.4 |
| TS + Pol II + AID + DSIF | 12.5 ± 1.1 |
aThe values represent average ± standard deviation from two to three independent experiments.
