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Interactions surrounding the hADAR3 mutations-corresponding locations in hADAR2 (10). (A) V351 (corresponding to A389 in hADAR3) mediates hydrophobic interactions with the edited base. (B) I446 (corresponding to V485 in hADAR3) facilitate anchoring the proton transfer residue E396. (C) Q488 and R510 (corresponding to E527 and Q549 respectively in hADAR3) contacts the orphan base of RNA substrate. (D) D695 (corresponding to Q733 in hADAR3) has a water-mediated contact to IHP.
