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. 2019 Sep 25;47(20):10801–10814. doi: 10.1093/nar/gkz815

Table 1.

Top mutations for activating ADAR3 predicted by Janus using E434a in active site as reference site

Scoreb Predicted change Score Predicted change
100 V485I 48 H496F
72 A389V 43 V435I
71 T556S 42 V436I
63 V586L 38 S411T
59 V598A 23 Q549R
48 H387R

aNumbering is based on human ADAR3.

bNormalized scores with highest scoring mutation set to 100.