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ITC analysis of 2′-dG binding to 2′-dG-II riboswitch mutants
| RNA | K D,dG (nM) | K rel (KD,mut/KD,wt) |
|---|---|---|
| env1 (wild type) | 34 ± 1 | 1 |
| env1 with xpt L2-L3 | 30 ± 2 | 0.88 |
| env1 U75A | 1600 ± 300 | 46 |
| env1 C76G | 100 ± 40 | 2.9 |
| env1 Δ(U75,C76) | 240 ± 50 | 7.1 |
| env1 A77U | 250 ± 10 | 7.4 |
| env1 C78A | 41 000 ± 9000 | 1200 |
| env1 C51U | 620 ± 180 | 18 |
| env1 G21A,C79U | 570 ± 30 | 17 |
| env1 C47,48U | 110 ± 10 | 3.2 |
| env1 C48A | 7.1 ± 1.4 | 0.21 |
