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. 2019 Aug 31;47(20):e126. doi: 10.1093/nar/gkz736

Figure 4.

Figure 4.

(A) Sequences of the Human Let-7e precursor and human LSU rRNA 4333-4345. Identical RNase A fragments are indicated as well as the Let-7e position reported by Pandorfini et al. to be m7G modified and the corresponding 2’ OMe G4340 position known to be modified in LSU rRNA and guided by snoRNA U60 (Krogh et al.). (B) Mutation rate difference versus –10*log(P-val) plot for 1239 Gs in 175 different human miRNAs. (C) Coverage and P-values obtained for the Human Let-7e precursor sequence. Position 18 is indicated. (D) Analysis of the power to detect m7G modification at position 18 in the human Let-7e. The curves show the power for 4 different detection levels of m7G modifications with the sequencing depth observed for Let-7e.