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DNA devices for microRNA biosensing. (A) DNA strand displacement based device with a fluorescence readout (128). (B) Gold nanoparticle and quantum dot based quench-and-release strategy (129). (C) Strand displacement coupled with RCA-based signal amplification (130). (D) DNA nanoswitches with a gel-based readout (132). Reproduced from ref 132. (E) A DNA walker that can detect two microRNAs in forward and backward steps (134).
