Table 1.

Dalbavancin Administration Schedule^a Based on SBA Titers Against the S. epidermidis Blood Isolate

Day of Therapy	i.v. Dalbavancin, mg	SBA Titers	Dalbavancin Serum Concentration, mg/L
Day 1	1500	n.a.	n.a.
Day 7	1500	n.a.	n.a.
Day 42	1500	1:128b	n.a.
Day 63	Not administered	1:512	32.8c
Day 112	1500	1:8b	0.6c (410.5d)
Day 133	Not administered	1:128	17.9c
Day 154	Not administered	1:16	n.a
Day 189	1500	1:2b	n.a.

Abbreviations: i.v., intravenous; SBA, serum bactericidal activity.

^aAfter day 42, it was decided to administer dalbavancin whenever an SBA titer ≤1:8 was detected; these circumstances accounted for through SBA titers previously reported as resulting in bacteriological cure in infective endocarditis [5].

^bSBA titer before i.v. dalbavancin administration.

^cThrough serum drug concentration.

^dPeak serum drug concentration (measured 15 minutes after dalbavancin i.v. administration).