Table 7.

Pharmacokinetic Parameters Of Nintedanib Soft Capsule And NDNB-SMEDDS (X±SD, n=5), **P<0.01, Compared Nintedanib Soft Capsule With NDNB-SMEDDS

Parameter	NDNB Soft Capsule	NNDB-SMEDDS
t1/2(h)	4.039±0.714	4.235±0.605
MRT0-12(h)	4.795±0.897	4.713±0.560
AUC0-t(μg∙h∙mL−1)	12.706±2.493	30.473±3.088**
Cmax (μg· mL−1)	2.6505±0.498	6.084±0.814**
Tmax(h)	3	2
K(h−1)	0.177±0.031	0.167±0.024
Cl/F(L∙h−1∙kg−1)	0.572±0.027	0.258±0.016
V/F(L∙kg−1)	3.087±0. 0.062	1.275±0.031**