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. 2019 Nov 7;25(41):6190–6204. doi: 10.3748/wjg.v25.i41.6190

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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TUNEL assay and H&E staining of liver tissues after acute liver failure induction. A: Apoptotic hepatocytes were stained red. At 36 h after ALF induction, the number of apoptotic cells was significantly lower in the menstrual blood stem cell (MenSC) treatment group than in the control group (× 20); B: High magnification images were shown (× 40); C: The livers of the ALF pigs without MenSC treatment showed a typical ALF histology with extensive haemorrhage, hepatocyte necrosis and adipose degeneration at 48 h. In contrast, ALF pigs with MenSC transplantation showed increased numbers of remaining hepatocytes and hepatic parenchymal cells (× 2); D: High magnification images were shown (× 20). MenSC treatment alleviated the progression of liver injury. ALF: acute liver failure; MenSC: menstrual blood stem cell.