Table 5.
Univariate logistic regression analysis showing the disease phenotypes of Crohn’s disease in correlation to circular RNA_103516 status as dependent variable
| Clinical variable | n | CircRNA_103765 + (%) |
Crude |
Adjusted |
||||
| OR | 95%CI | P value | OR | 95%CI | P value | |||
| Gender | ||||||||
| Male | 48 | 66.7 | ||||||
| Female | 42 | 64.3 | 1.11 | 0.465-2.655 | 0.813 | NS | ||
| Age | ||||||||
| < 40 yr | 47 | 57.4 | ||||||
| ≥ 40 yr | 43 | 74.4 | 2.155 | 0.879-5.281 | 0.093 | NS | ||
| Smoking status | ||||||||
| Never | 60 | 68.3 | ||||||
| Past or current use | 30 | 60.0 | 1.439 | 0.579-3.577 | 0.434 | NS | ||
| Disease location of CD | ||||||||
| L1 | 37 | 64.7 | ||||||
| L2 | 20 | 64.7 | 0.524 | 0.094-2.930 | 0.462 | NS | ||
| L3 | 33 | 63.3 | 0.522 | 0.082-3.364 | 0.496 | |||
| Disease activity of CD | ||||||||
| Mild | 19 | 47.4 | ||||||
| Moderate | 40 | 82.5 | 5.238 | 1.554-17.653 | 0.008 | 4.886 | 1.384-17.251 | 0.014 |
| Severe | 15 | 80.0 | 4.444 | 0.941-21.001 | 0.025 | 4.416 | 0.084-22.054 | 0.043 |
| Disease behavior of CD | ||||||||
| B1 | 39 | 48.7 | ||||||
| B2 | 33 | 78.8 | 3.910 | 1.376-11.110 | 0.011 | 3.641 | 1.245-10.650 | 0.018 |
| B3 | 18 | 77.8 | 3.684 | 1.028-13.202 | 0.045 | 4.375 | 1.147-16.690 | 0.031 |
| Medications | ||||||||
| 5-ASA | 80 | 73.8 | 1.309 | 0.340-5.035 | 0.696 | NS | ||
| Corticosteroids | 50 | 74.0 | 2.329 | 0.959-5.655 | 0.062 | NS | ||
| Immunosuppressants | 28 | 67.9 | 1.161 | 0.450-2.998 | 0.758 | NS | ||
| Anti-TNF-α | 13 | 76.9 | 1.905 | 0.483-7.505 | 0.357 | NS | ||
| Surgery | 4 | 75.0 | 1.607 | 0.160-16.130 | 0.687 | NS | ||
The data are shown with crude and adjusted odds ratios and 95% confidence intervals accordingly. L1: Terminal ileum; L2: Colon; L3: Ileocolon; B1: Non-stricture and non-penetrating; B2: Stricturing; B3: Penetrating; CD: Crohn’s disease; 5-ASA: 5-aminosalicylic acid; TNF-α: Tumor necrosis factor α; NS: No significance; OR: Odds ratio; CI: Confidence interval; CircRNA: Circular RNA.