Table 6.
Univariate logistic regression analysis showing the disease phenotypes of ulcerative colitis in correlation to circular RNA_103516 status as dependent variable
| Clinical variable | n | CircRNA_103765 + (%) |
Crude |
Adjusted |
||||
| OR | 95%CI | P value | OR | 95%CI | P value | |||
| Gender | ||||||||
| Male | 38 | 52.6% | ||||||
| Female | 52 | 59.6% | 1.329 | 0.571-3.090 | 0.509 | NS | ||
| Age | ||||||||
| < 40 yr | 40 | 60.0% | ||||||
| ≥ 40 yr | 50 | 54.0% | 0.783 | 0.337-1.817 | 0.568 | NS | ||
| Smoking status | ||||||||
| Never | 67 | 69.7% | ||||||
| Past or current use | 23 | 47.8% | 0.619 | 0.239-1.604 | 0.323 | NS | ||
| Disease location of UC | ||||||||
| E1 | 36 | 44.4% | ||||||
| E2 | 30 | 60.0% | 1.875 | 0.702-5.009 | 0.210 | NS | ||
| E3 | 24 | 70.8% | 3.036 | 1.012-9.107 | 0.048 | |||
| Disease severity of UC | ||||||||
| Mild | 30 | 60.0% | ||||||
| Moderate | 31 | 70.9% | 1.630 | 0.562-4.729 | 0.369 | NS | ||
| Severe | 15 | 93.3% | 9.333 | 1.080-80.627 | 0.042 | 10.803 | 1.171-94.687 | 0.036 |
| Medications: n (%) | ||||||||
| 5-ASA | 87 | 57.5% | 0.786 | 0.143-2.037 | 0.342 | NS | ||
| Corticosteroids | 41 | 70.7% | 1.827 | 0.762-5.234 | 0.084 | NS | ||
| Immunosuppressants | 14 | 71.4% | 1.234 | 0.673-3.238 | 0.705 | NS | ||
| Anti-TNF-α | 4 | 50.0% | 0.385 | 0.051-2.919 | 0.355 | NS | ||
| Surgery | 1 | 0.0% | 0.000 | 0.000- | 1.000 | NS | ||
The data are shown with crude and adjusted odds ratios and 95% confidence intervals accordingly. E1: Rectum; E2: Left side; E3: Extensive; UC: Ulcerative colitis; 5-ASA: 5-aminosalicylic acid; TNF-α: Tumor necrosis factor α; NS: No significance; OR: Odds ratios; CI: Confidence intervals; CircRNA: Circular RNA.