Table 2.
Risk of incident AD pre-dementia associated with time-dependent depression dimensions (separate models for each dimension) and depressive symptomatology
| items | HR | (95%CI) | pc | |
|---|---|---|---|---|
| Women (294 events/3374) | ||||
| Depression dimensions | ||||
| Somatic affecta | (1, 2, 5, 7, 11, 13, 20) | 1.08 | (1.02;1.14) | 0.007 |
| Depressed affecta | (3, 6, 14, 17, 18) | 1.05 | (1.01;1.10) | 0.02 |
| Positive affectb | (4, 8, 12, 16) | 1.04 | (1.00;1.08) | 0.04 |
| Interpersonal challenge | (9, 10, 15, 19) | 1.08 | (1.00;1.16) | 0.04 |
| Total score | 1.10 | (1.03;1.07) | 0.003 | |
| Depressive symptomatology: high | (Total score ≥ 16) | 1.39 | (1.08;1.80) | 0.01 |
| Men (139 events/2243) | ||||
| Depression dimensions | ||||
| Somatic affecta | (1, 2, 5, 7, 11, 13, 20) | 1.08 | (0.96;1.19) | 0.14 |
| Depressed affecta | (3, 6, 14, 17, 18) | 0.98 | (0.88;1.10) | 0.72 |
| Positive affectb | (4, 8, 12, 16) | 1.02 | (0.96;1.09) | 0.58 |
| Interpersonal challenge | (9, 10, 15, 19) | 1.07 | (0.92;1.23) | 0.41 |
| Total scorea | 1.06 | (0.93;1.20) | 0.38 | |
| Depressive symptomatology: high | (Total score ≥ 16) | 0.92 | (0.50;1.68) | 0.79 |
astandardised to 0–12 scale
breversed so that a high score reflects a low positive affect
cCox proportional hazard models with age as the time-scale, adjusted for study centre, education (>5 years), Apoe4 and the following time-dependent variables: diabetes (no/yes), ischemic disease (no/yes), dependency (3 levels), anxiolytic or antidepressant consumption (no/yes)