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. 2019 Nov 11;9:16480. doi: 10.1038/s41598-019-52952-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Western blots, specific activity, and histology. (A) Western blots showing phosphorylated PDH E1α subunit (pE1α), total phosphorylated PDH E1α subunit in tissue lysates from DIO control and DIO DKO livers (n = 3 livers). GAPDH serves as a loading control. The images were collected from three gels. Raw images of these three gels are shown in Supplementary Information (Fig. S5). (B) PDH specific activity; Representative Red Oil O stains from (C) DIO control and (D) DIO DKO livers. The red color in each image is attributed to stained lipids within the liver. The scale bars are 20 µm. The bar graph in (B) reflects the mean ± SD (n = 3 per group) with a statistical significance of differences indicated by “*” (P < 0.05) and “**” (P < 0.001).