Figure 3.

Astrocyte-specific knockout mice showed increased aggressive behaviour. Aggressive behaviour of male cKO and control mice was assessed using the resident-intruder test. Resident mice were confronted in their home cage with an unfamiliar mouse for 5 min. The number of attacks (A), latency until the first attack (B), and cumulative time of attacks (C) were analysed (n = 11–14). In case of no attack, the latency of first attack was set to 300 s and cumulative time of attacks was set to 0. Statistical significance was assessed with one-way ANOVA and Tukey’s post-hoc test (***p < 0.001).