Table 1.
Concentrations of histamine and 1-methylhistamine in selected brain regions.
| Brain region | Concentration [pM/mg tissue] | |||
|---|---|---|---|---|
| Hrh1 f/f | GFAP-Cre Hrh1f/f | CaMKII-Cre Hrh1f/f | ||
| Hypothalamus | HA | 0.64 ± 0.301 | 0.84 ± 0.216 | 1.26 ± 0.502* |
| 1-MH | 1.22 ± 0.409 | 0.99 ± 0.423 | 1.32 ± 0.412 | |
| Hippocampus | HA | 0.09 ± 0.045 | 0.15 ± 0.044 | 0.22 ± 0.161 |
| 1-MH | 0.51 ± 0.104 | 0.52 ± 0.207 | 0.37 ± 0.097 | |
| Prefrontal cortex | HA | 0.09 ± 0.024 | 0.28 ± 0.129 | 0.25 ± 0.212 |
| 1-MH | 0.48 ± 0.399 | 0.49 ± 0.369 | 0.56 ± 0.269 | |
| Cortex | HA | 0.09 ± 0.012 | 0.13 ± 0.047 | 0.19 ± 0.15 |
| 1-MH | 0.23 ± 0.117 | 0.22 ± 0.131 | 0.19 ± 0.11 | |
| Cerebellum | HA | 0.06 ± 0.032 | 0.09 ± 0.034 | 0.13 ± 0.117 |
| 1-MH | 0.08 ± 0.038 | 0.07 ± 0.076 | 0.16 ± 0.228 | |
| Diencephalon | HA | 0.2 ± 0.047 | 0.26 ± 0.081 | 0.33 ± 0.119 |
| 1-MH | 0.62 ± 0.3 | 0.67 ± 0.211 | 0.71 ± 0.363 | |
n = 6. Statistical differences among the groups were determined using one-way ANOVA with Tukey’s post-hoc test (*p < 0.05). HA: histamine, 1-MH: 1-methylhistamine.