Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 11;9:16490. doi: 10.1038/s41598-019-52893-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Chemotherapy altered the fecal bacteriome over time. (A) Alpha diversity as measured by Shannon Index decreased as an effect of time, and was decreased between baseline and post-6 injections in the chemotherapy group but not the vehicle group. (B) This decrease was associated with an increase in Lactobacillus as an effect of time and was increased between baseline and post-6 injections in the chemotherapy group but not the vehicle group and (C) was negatively correlated to alpha diversity. (D) Weighted UniFrac distances (beta diversity) differentiated between chemotherapy and vehicle groups, and (E,F) biplots for Lactobacillus (black arrows) suggest that relative abundance of this genus drive differences across time, especially in the chemotherapy group. n = 6–10/group; *p < 0.05 repeated measures ANOVA for time; ^#p < 0.05 vs baseline.