Table 1.
Colonic gene expression of inflammatory markers ± SEM (arbitrary units, relative standard curve normalized to Eef2).
| Gene | Time Post-Final Treatment | Treatment | Proximal Colon | Distal Colon |
|---|---|---|---|---|
| IL-1β | 72 h | VEHICLE | 1.32 ± 0.18 | 1.00 ± 0.07 |
| CHEMOTHERAPY | 1.33 ± 0.2 | 1.07 ± 0.08 | ||
| Il-2 | 72 h | VEHICLE | 0.23 ± 0.08 | 0.59 ± 0.14 |
| CHEMOTHERAPY | 0.17 ± 0.09 | 0.47 ± 0.16 | ||
| Il-6 | 72 h | VEHICLE | 1.32 ± 0.18 | 1.00 ± 0.07 |
| CHEMOTHERAPY | 1.33 ± 0.2 | 1.07 ± 0.08 | ||
| Tnfα | 72 h | VEHICLE | 1.13 ± 0.11 | 0.96 ± 0.07 |
| CHEMOTHERAPY | 1.18 ± 0.12 | 0.74 ± 0.08 * | ||
| Cxcl1 | 72 h | VEHICLE | 0.59 ± 0.25 | 0.45 ± 0.06 |
| CHEMOTHERAPY | 0.64 ± 0.28 | 0.51 ± 0.07 | ||
| Mmp9 | 72 h | VEHICLE | 0.80 ± 0.13 | 0.57 ± 0.04 |
| CHEMOTHERAPY | 1.39 ± 0.13# | 0.53 ± 0.04 |
n = 8–10/group; *p < 0.05; #p < 0.01.