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. 2019 Nov 11;9:16452. doi: 10.1038/s41598-019-52795-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The overall structure of CAMKK2-KD bound to GSK650394 and overlay of all ligand-bound CAMKK2-KD structures from this work. (A,B) Cartoon representation of CAMKK2-KD showing the conserved kinase domain architecture consisting of N- and C-lobes connected by an intervening hinge region (main chain atoms shown as sticks). Major structural elements within the kinase domain are highlighted. The kinase domain α-C and P-loop are shown in purple. The R-spine is shown as a yellow surface, and side chains for residues within the R-spine are shown as sticks. Residues within the RP-insert are not part of the final model and this region is represented by a dashed black line. (C) Overlay of CAMKK2-KD structures (shown as ribbon) highlighting differences in the protein P-loop (in purple). Green spheres represent Cα atoms for residues Ser175 within the protein P-loop.