Table 3.

Binding affinities and thermodynamic parameters for individual ITC experiments.

Compound	KD (nM)		ΔG (kJ/mol)		ΔH (kJ/mol)		TΔS (kJ/mol.K)
	Run 1	Run 2	Run 1	Run 2	Run 1	Run 2	Run 1	Run 2
GSK650394	5.8	6.7	−46.2	−45.8	−87.5	−79.1	−41.3	−33.2
ALK-IN-1	2.5	2.0	−46.0	−45.7	−43.0	−40.7	5.8	4.9
BI 2536	4.4	3.4	−47.5	−45.7	−58.0	−55.3	−10.5	−9.6
CP-673451	2.6	1.5	−48.2	−49.5	−55.2	−54.5	−7.1	−5.0