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. 2019 Nov 11;9:16420. doi: 10.1038/s41598-019-52896-x

Table 1.

Key regulators and their topological properties.

Sl. No. ID Gene Function Degree
(k)		 Closeness centrality
(CC)		 Betweenness centrality
(CB)		 Eigenvector centrality
(CE)		 Subgraph centrality
(CS)
1 AHSA1 Activator of Hsp90 ATPase activity 1 Positive regulation of ATPase 75 0.379262 0.00331 0.054588 2.47E + 23
2 CCT4 Chaperonin containing TCP1 subunit 4 Protein folding 66 0.384435 0.003334 0.033523 9.29E + 22
3 CUL7 Cullin 7 Ubiquitin-dependent protein catabolism 270 0.435916 0.034463 0.151248 1.89E + 24
4 EIF3A Eukaryotic translation initiation factor 3 subunit A Translation pre-initiation complex formation 85 0.37006 0.002209 0.079073 5.18E + 23
5 HSPA5 Heat shock protein family A (Hsp70) member 5 Activation of signaling protein activity involved in unfolded protein response 111 0.408758 0.012349 0.062591 3.24E + 23
6 NOP2 NOP2 nucleolar protein rRNA base methylation, 68 0.375317 0.001319 0.076741 4.88E + 23
7 RANBP2 RAN binding protein 2 Protein sumoylation 72 0.386242 0.004881 0.031476 8.19E + 22
8 RPL11 Ribosomal protein L11 Ribosomal large subunit assembly 83 0.383638 0.001239 0.114333 1.08E + 24
9 RPL15 Ribosomal protein L15 Nuclear-transcribed mRNA catabolic process 79 0.382201 0.001289 0.109354 9.91E + 23
10 RPL19 Ribosomal protein L19 Nuclear-transcribed mRNA catabolic process 78 0.381856 0.000469 0.113259 1.06E + 24
11 RPL23A Ribosomal protein L23a Ribosomal large subunit assembly 84 0.379602 0.001182 0.109817 9.99E + 23
12 RPL3 Ribosomal protein L3 Ribosomal large subunit assembly 67 0.385588 0.000788 0.100707 8.41E + 23
13 RPL5 Ribosomal protein L5 Ribosomal large subunit assembly 92 0.383141 0.001438 0.114815 1.09E + 24
14 RPL6 Ribosomal protein L6 Ribosomal large subunit assembly 113 0.39809 0.003601 0.129049 1.38E + 24
15 RPLP0 Ribosomal protein lateral stalk subunit P0 Nuclear-transcribed mRNA catabolic process 88 0.394955 0.002486 0.110764 1.02E + 24
16 RPS11 Ribosomal protein S11 Nuclear-transcribed mRNA catabolic process 74 0.376943 0.000751 0.102129 8.64E + 23
17 RPS8 Ribosomal protein S8 Nuclear-transcribed mRNA catabolic process 120 0.394218 0.004481 0.126136 1.32E + 24
18 RPSA Ribosomal protein SA Ribosomal small subunit assembly 79 0.378002 0.002864 0.094957 7.47E + 23
19 SNU13 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6, U5) mRNA splicing, via spliceosome 87 0.370245 0.003088 0.072649 4.37E + 23