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. 2019 Nov 11;9:16488. doi: 10.1038/s41598-019-52829-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plot illustrates the distribution of the average number of streamlines (NOS) between the 10 significantly reduced tracts found in MSA patients using threshold-free network based statistics (TFNBS). NOS values were Z-transformed to calculate the global mean value comprising all significant connections; HC: healthy controls; PD: Parkinson’s disease group; MSA: multiple system atrophy group. Plot width represents the frequency (density) of values; the height indicates the upper (max) and lower (min) limits.