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. 2019 Nov 11;9:16461. doi: 10.1038/s41598-019-52839-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vascular ET-1 receptors expression and effect of ET-1 on phenylephrine contraction in MRA. ET_A and ET_B mRNA levels in aortic (a) and mesenteric (b) segments from WKY and SHR; *P < 0.05 by Student's t test. (c) Effect of ET-1 (1 nM, 90 min) on the concentration-response curve to phenylephrine (Phe) in endothelium-intact (E+) and denuded (E-) segments from WKY and SHR; *P < 0.05 by two-way ANOVA with repeated measures followed by Sidak post hoc test. Differences of the area under the concentration-response curve (dAUC) to Phe in E+ and E- segments from SHR are also shown; *P < 0.05 by Student's t test. (d) Effect of BQ123 (1 µM) and BQ788 (1 µM) on the response to Phe in E+ segments from SHR treated with ET-1; *P < 0.05 vs control; ^#P < 0.05 vs ET-1 by two-way ANOVA with repeated measures followed by Tukey post hoc test. (e) Effect of ET-1 on the vascular expression of PPARγ; statistical analysis by Student's t test. n denotes number of experiments.