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. 2019 Nov 11;9:16461. doi: 10.1038/s41598-019-52839-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Role of nitric oxide and oxidative stress on ET-1-induced potentiation of phenylephrine response in MRA from hypertensive rats. (a) Effect of 0.1 mM L-NAME on the concentration-response curve to phenylephrine (Phe) in control and ET-1-incubated (1 nM, 90 min) segments from SHR; *P < 0.05 by two-way ANOVA with repeated measures followed by Sidak post hoc test. Differences of the AUC (dAUC) to Phe in the presence and the absence of L-NAME are also shown; *P < 0.05 by Student's t test. (b) Effect of ET-1 on eNOS mRNA levels in vascular segments; statistical analysis by Student's t test. (c) Quantification of nitric oxide (NO) release and (d) NADPH oxidase activity in control and ET-1-incubated segments from SHR; statistical analysis by Student’s t test. (e) Effect of 0.5 µM ML-171 on the concentration-response curve to Phe in control and ET-1-incubated segments from SHR; *P < 0.05 by two-way ANOVA with repeated measures followed by Sidak post-test. (f) Effect of ET-1 and L-NAME on the concentration-response curve to acetylcholine (ACh) in segments from SHR; *P < 0.05 vs Control; ^#P < 0.05 vs ET-1 by two-way ANOVA with repeated measures followed by Sidak post hoc test. (g) Quantification of ACh-induced NO release in control and ET-1-incubated segments from SHR; statistical analysis by Student's t test. n denotes number of experiments.