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. 2019 Nov 11;9:16461. doi: 10.1038/s41598-019-52839-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Contribution of AP-1 to the ET-1-induced oxidative stress and COX-2 expression in VSMC from hypertensive rats. Effect of SP600125 (SP, 20 µM) on NOX-1 mRNA levels (a), NADPH oxidase activity (b) and COX-2 protein expression (c) and mRNA levels (d) induced by ET-1 (0.1 µM, 1 h). *P < 0.05 vs control (Ctrl) and ^#P < 0.05 vs ET-1 by Student's t-test. (e) Time-course of ET-1 (0.1 µM)-induced p-JNK1/2 protein expression in VSMC from SHR; *P < 0.05 vs control (0´) by one-way ANOVA. A representative blot is shown in the upper panel; lower panel shows reblotting of upper panel with JNK2 antibody. (f) Effect of ET-1 (0.1 µM, 1 h) on c-jun mRNA levels. Statistical analysis by Student's t-test. n denotes number of experiments. Full-length blots are presented in Supplementary Fig. S4.