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. 2019 Nov 11;9:16500. doi: 10.1038/s41598-019-52477-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neurologic deficit score (NDS) (A) and Kaplan-Meier survival curve (B) in the experimental groups. NNC: normoxic control under normothermia; O₂_0h, O₂_1h, O₂_3h, and O₂_5h: ventilated with 100% oxygen for 0, 1, 3 and 5 h under targeted temperature management; *p < 0.05 compared with NNC; ^#p < 0.05 compared with O₂_0h; ^&p < 0.05 compared with O₂_1h. n = 16 in each group.