Table 1.
Baseline variables and characteristics of CPR
| Group | NNC | O2_0h | O2_1h | O2_3h | O2_5h |
|---|---|---|---|---|---|
| Body weight, g | 312.1 ± 21.5 | 319.8 ± 27.9 | 313.1 ± 35.2 | 311.4 ± 34.7 | 313.9 ± 30.3 |
| Heart rate, bpm | 412.0 ± 28.1 | 420.6 ± 36.7 | 413.3 ± 22.7 | 428.0 ± 25.1 | 422.4 ± 27.5 |
| MAP, mmHg | 125.8 ± 8.1 | 121.4 ± 10.9 | 118.7 ± 16.2 | 122.8 ± 8.8 | 122.2 ± 11.2 |
| Temperature, °C | 37.5 ± 0.1 | 37.5 ± 0.3 | 37.5 ± 0.4 | 37.4 ± 0.3 | 37.5 ± 0.2 |
| LVEF, % | 78.5 ± 5.9 | 77.9 ± 4.1 | 77.7 ± 6.3 | 77.0 ± 5.9 | 78.5 ± 5.7 |
| Asphyxial time to cardiac arrest, s | 165.3 ± 15.6 | 172.3 ± 11.8 | 168.9 ± 13.6 | 169.8 ± 16.7 | 170.1 ± 17.3 |
| CPR duration, s | 75.5 ± 34.4 | 73.1 ± 15.6 | 79.6 ± 23.1 | 74.2 ± 33.0 | 82.7 ± 29.8 |
| Number of shocks, n | 0.3 ± 0.4 | 0.2 ± 0.5 | 0.4 ± 0.6 | 0.4 ± 0.6 | 0.4 ± 0.5 |
| Total epinephrine, µg | 7.1 ± 2.4 | 6.5 ± 1.3 | 6.2 ± 2.0 | 6.2 ± 2.0 | 6.8 ± 1.3 |
| ROSC rate, % | 100 | 100 | 100 | 100 | 100 |
CPR: cardiopulmonary resuscitation; NNC: normoxic control under normothermia; O2_0h, O2_1h, O2_3h, and O2_5h: ventilated with 100% oxygen for 0, 1, 3 and 5 h under targeted temperature management; bpm: beats per minute; MAP: mean arterial pressure; LVEF: left ventricular ejection fraction; ROSC: return of spontaneous circulation. n = 16 in each group.