Table 5.
Neuronal functions and molecular processes associated with particular SNP sets and temperament profiles, including reliable (R), sensitive (S), and antisocial (A) profiles, and numbers of subjects and of genes mapped to each SNP set
| Neuronal functions | SNP set | SNP set name | genes n | subjects n | Temperament profiles |
|---|---|---|---|---|---|
| Neuroplasticity | G_28_15 | Estrogen neuroplasticity | 29 | 101 | S or A |
| G_41_33 | GPCR neuroplasticity | 15 | 56 | S | |
| G_28_10 | WD/CDK neuroplasticity | 8 | 46 | R | |
| G_38_23 | Sensory sensitivity | 16 | 39 | S | |
| G_30_28 | Hippocampal synaptic plasticity | 10 | 34 | S | |
| Long-term memory | G_12_1 | Episodic memory | 66 | 146 | R |
| G_7_3 | Neurogenesis | 128 | 133 | S or A | |
| G_12_11 | Ras-AKT interaction | 4 | 105 | R, S, or A | |
| G_31_8 | Neurotrophin | 60 | 54 | S or A | |
| Energy production | G_26_14 | Glucose transport | 25 | 46 | S or A |
| G_25_20 | Fatty acid oxidation | 3 | 33 | R | |
| G_36_29 | Electron transport | 49 | 25 | S | |
| Cognitive flexibility | G_21_18 | Cognitive flexibility | 15 | 116 | R or A |
| G_38_17 | MAPK memory enhancement | 13 | 14 | R | |
| G_5_3 | Regulation pathways | 2 | 172 | R | |
| Resistance to stress, injury, & aging | G_8_8 | Global inositol/chemokine pathways | 286 | 224 | R |
| G_12_8 | Neuroprotection | 111 | 173 | R, A, or S | |
| G_16_15 | Interleukin-2 neuroimmune response | 7 | 94 | A | |
| G_21_17 | TGFβ resistance to aging | 26 | 67 | R | |
| G_33_33 | TGFβ memory enhancement | 13 | 49 | R | |
| G_30_10 | TNF-based resilience | 6 | 47 | R | |
| G_37_6 | Methylation-based gene silencing | 23 | 26 | R | |
| G_20_2 | Enhanced memory | 18 | 25 | R | |
| Cholinergic neuromodulation | G_13_10 | Cholinergic neuromodulation | 17 | 148 | R |
| G_13_12 | Acetylcholine biosynthesis | 1 | 78 | S or R | |
| G_21_16 | Acetylcholine biosynthesis | 1 | 37 | S or A | |
| G_25_3 | Acetylcholine biosynthesis | 2 | 16 | S or A | |
| Fear conditioning | G_30_9 | ERK-IP3-PKC stress interaction | 52 | 69 | S |
| G_39_21 | RGS negative emotionality | 5 | 56 | S | |
| G_41_37 | PI3K-MAPK cognitive function | 11 | 41 | S | |
| Stress reactivity | G_7_2 | GPCR dysregulation | 147 | 211 | S or A |
| G_9_2 | Serotonin-cytokine interaction | 11 | 140 | S or A | |
| G_16_5 | ERK-IP3-PKC stress memory | 1 | 87 | R | |
| G_14_12 | Ras-based stress memory | 22 | 83 | A | |
| G_21_3 | cellular senescence | 39 | 60 | S or A | |
| G_11_7 | HPA stress reactivity | 11 | 26 | S or A | |
| G_33_4 | ERK-PKA interaction | 6 | 24 | S or A | |
| G_38_38 | Ion permeability | 18 | 38 | S | |
| G_22_6 | Blood-brain barrier permeability | 30 | 37 | S or A | |
| G_42_39 | Approach-avoidance conflict | 11 | 19 | S | |
| Conditioning of dopaminergic activation | G_16_1 | PI3K-based memory | 11 | 108 | A |
| G_35_22 | PI3K-based memory | 5 | 43 | S or A | |
| G_39_26 | mTOR myelination | 26 | 20 | S or A | |
| Conditioning of neuroexcitability | G_7_7 | Olfaction | 58 | 145 | A |
| G_13_3 | ERK-conditioned impulsivity | 21 | 95 | S or A | |
| G_35_7 | PI3K-based memory | 12 | 32 | A | |
| G_37_14 | Neuroexcitability | 12 | 21 | A | |
| G_36_18 | Brain RNA biosynthesis | 4 | 19 | A | |
| Habit extinction | G_38_13 | Glucuronidase habit extinction | 7 | 60 | R, A, or S |
| G_19_3 | Glucuronidase habit extinction | 5 | 48 | S | |
| G_40_5 | Mannosidase habit extinction | 3 | 16 | A |