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. 2019 Nov 5;13:387. doi: 10.3389/fnhum.2019.00387

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Copyright © 2019 Berg, Sinha and Gluck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The genetic and lifestyle factors that contribute to Alzheimer’s disease (AD) risk and impaired cognitive function in African Americans. Overall, aerobic fitness influences brain structure and function, which then affects cognition. Apolipoprotein E (APOE) ε4 directly impacts brain structure and function via dysfunctional lipid metabolism, leading to aberrant hippocampal hyperactivation and therefore, impaired mnemonic discrimination of episodic memories. APOE ε4 indirectly influences the effects of aerobic exercise on hippocampal plasticity and volume through the regulation of BDNF. ABCA7 rs115550680 directly impacts the brain through amyloid-β (Aβ) facilitated tauopathy, which negatively influences medial temporal lobe (MTL) functional connectivity, and consequently, behavioral generalization. ABCA7 rs3764650 moderates the effects of aerobic fitness through dysfunctional lipid metabolism and ABCA7 expression, which indirectly impairs behavioral generalization.