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. 2019 Nov 5;9:377. doi: 10.3389/fcimb.2019.00377

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Copyright © 2019 Zhu, Xia, Zhou, Li, Guo, Zhu, Zheng, Wang, Yang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HBV specific CD8⁺ T cell responses in the control, pSM2/HBV HI, and pAAV/HBV1.2 HI mice. On day 14 after HI, liver infiltrated lymphocytes were isolated and stimulated with HBV core peptide. The frequency of CD8⁺IFN-γ⁺, CD8⁺IL-2⁺, and CD8⁺TNF-α⁺ cells was detected using FACS. Control mice, n = 7; pSM2/HBV HI mice, n = 5; pAAV/HBV1.2 HI mice, n = 5. ***p < 0.001.