TABLE 1.
Non-apoptotic functions of caspases in different cell types.
| Cell type | Model and caspase involved | References | |
| Inflammasome | Astrocytes | Primary cortical astrocytes from mice with Aβ1–42 (caspase-1) | Ebrahimi et al., 2018 |
| Primary glial cultures from WT, Nlrc4–/–, Nlrp3–/– and Asc–/– mice with LPC(caspase-1) | Freeman et al., 2017; | ||
| Human primary astrocytes with ATP (caspase-1) | Minkiewicz et al., 2013 | ||
| SOD1 mouse model/ALS patients (caspase-1) | Johann et al., 2015 | ||
| Intracerebral hemorrhage mouse model (caspase-1) | Wang et al., 2017 | ||
| Mouse primary astrocytes with methamphetamine (caspase-11) | Du et al., 2017 | ||
| Microglia | EAE mouse model (caspase-8) | Zhang et al., 2018 | |
| Neurons | Primary cultures of human neurons under serum-deprived conditions (caspase-1) | Kaushal et al., 2015 | |
| APPSwe/PS1dE9 transgenic mice (caspase-1) | Tan et al., 2014 | ||
| Dopaminergic neurons from PD patients (caspase-1) | von Herrmann et al., 2018 | ||
| ODCs | Administration prenatal of dexamethasone to mice (caspase-1) | Maturana et al., 2017 | |
| Pyroptosis | Astrocytes | Ischemia induced by the oxygen-glucose deprivation in primary cultured astrocytes from rats (caspase-1) | Xia et al., 2018 |
| Stroke model in rats (caspase-1) | |||
| Cultured rat cortical astrocytes with bilirubin (caspase-1) | Feng et al., 2018 | ||
| Sepsis model in mice and rats induced by LPS (caspase-1) | Li et al., 2019; Sun et al., 2019 | ||
| Neurons Neurons | Primary cultures of human neurons under serum-deprived conditions (caspase-1) | Kaushal et al., 2015 | |
| Cultured cortical neurons from rats with Aβ (caspase-1) | Tan et al., 2014 | ||
| SCI model in rats (caspase-1, caspase-11) | Lin et al., 2016; de Rivero Vaccari et al., 2008 | ||
| Caspase-1-/- mice subjected to controlled cortical impact injury (caspase-1) | Liu et al., 2018 | ||
| Ischemic stroke model in mice (caspase-1, caspase-11) | Fann et al., 2018 | ||
| Ocular hypertension-injured retina in mice (caspase-1) | Pronin et al., 2019 | ||
| ODCs | EAE mouse model (caspase-1) | McKenzie et al., 2018 | |
| MS patients (caspase-1) | |||
| Necroptosis | ODCs | EAE and Cuprizone mouse models of MS and in MS patients (caspase-8) | Ofengeim et al., 2015 |
| Osmotic demyelination syndrome model in mice (caspase-8) | Bouchat et al., 2018 | ||
| Neonatal rats subjected to hypoxia-ischemia (caspase-8) | Qu et al., 2017 | ||
| Neurons | Global cerebral ischemia/reperfusion in CA1 neurons in rats (caspase-8) | Xu et al., 2016 | |
| Subarachnoid hemorrhage induced brain injury model in rats (caspase-8) | Chen et al., 2018; Yuan et al., 2019 | ||
| Models of retinal degeneration in rats (caspase-8) | Jang et al., 2019 | ||
| Astrocytes | Mouse spinal cord astrocytes with LPS or TNF-α with zVAD (caspase-8) | Fan et al., 2016 | |
| SCI model in mice (caspase-8) | |||
| Microglia | Mice stereotaxically injected with LPC (caspase-8) | Lloyd et al., 2019 | |
| Synapses | Neurons | Cultured neurons subjected to neurotrophic factor deprivation (caspase-3, caspase-6, caspase-9) | Simon et al., 2012 |
| Caspase-3 knockout mice (caspase-3) | Ertürk et al., 2014 | ||
| J20 APP transgenic mice (caspase-2) | Pozueta et al., 2013 | ||
| Caspase-9–/– mice (caspase-9) | Ohsawa et al., 2010 | ||
| Caspase-3–/–neonatal mice (caspase-3) | Gu et al., 2017 | ||
| Caspase-3 knockout mice and rats (caspase-3) | Li et al., 2010 | ||
| Tg2576-APPSwe mice (caspase-3) | D’Amelio et al., 2011 | ||
| Autophagy | Neurons | Primary cortical neurons from wt and casp2–/– mice with rotenone (caspase-2) | Tiwari et al., 2011 |
| PC12 cells and cortical neurons from rats with Aβ1–42 (caspase-3) | Wang et al., 2017 | ||
| APPSwe/PS1dE9 transgenic mice (caspase-3) | |||
| Mitochondria Biogenesis | Neurons | Dopaminergic cell line (procaspase-3) | Kim et al., 2018 |