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. 2019 Nov 5;9:1175. doi: 10.3389/fonc.2019.01175

Figure 2.

Figure 2

STAT3 knockdown inhibits aerobic glycolysis in OSCC cells. (A) Glucose consumption assay was used to detect the glucose consumption in STAT3-knockdown Cal-27 and Tca8113 cells. The data showed that down-regulation of STAT3 led to lower glucose consumption in Cal-27 and Tca8113 cells. (B) Lactate production assay was used to detect the lactate production in STAT3-knockdown Cal-27 and Tca8113 cells. The data showed that down-regulation of STAT3 led to lower lactate production in Cal-27 and Tca8113 cells. (C) PKM2 mRNA levels in STAT3-knockdown Cal-27 and Tca8113 cells were examined by qRT-PCR. (D) LDHA mRNA levels in STAT3-knockdown Cal-27 and Tca8113 cells were examined by qRT-PCR. Each assay was carried out in triplicate. Results were shown as means ± SD. *P < 0.05.