Table 1.

Prognostic Indicators for tumour progression

Markers to predict response to therapy	A. Steroid-regulated proteins- Cathepsin D and pS2
Markers to monitor drug resistance	P-glycoprotein (a transmembrane protein)
Growth factors and receptors	Epidermal growth factor receptors, erb-2 oncoprotein, insulin and insulin-like growth factor receptors, transforming growth factor - receptors, fibroblast growth factor receptors and the somatostatin receptors
Tumour angiogenesis	Microvascular density-independent prognosticator
Tumour growth fraction	Ki 67 Antibody, Proliferating Cell Nuclear Antigen (PCNA) & P27 KiP1 Gene
Tumour suppressor genes	pRb, p53
Anti-apoptosis genes	bcl-2
Nm23 Anti-metastasis gene	Higher in melanoma cell line with low metastasis
DNA repair genes- Microsatellite instability(MSI)
Miscellaneous	K-ras and c-myc oncogenes transforming factors-TGF-a, TGG-b Adhesion proteins- E-cadherin and CD 44 Matrix metaloproteases and inhibitors