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. 2019 Nov 5;10:1068. doi: 10.3389/fgene.2019.01068

Table 4.

Quantitative trait loci (QTL) associated with gestation length in the Holstein-Friesian population*.

BTA Start End No SNP <10-5 Strongest SNP Strongest SNP position + Allele + Allele Freq P-value No genes Candidate gene(s)
1 106544365 106573019 6 rs211674422a 106562729 G 0.795 1.35 x10-6 0
2 125797480 125824150 8 rs134618553a 125822265 A 0.540 5.81 x10-6 0
3 53231290 53254980 12 rs11015107a 53235224 C 0.010 4.11 x10-7 0
3 103958875 104046559 2 rs799224682c 104046559 C 0.982 1.86 x10-7 3 TMEM269
4 7044130 7518266 43 rs472554192a 7514459 A 0.021 7.10 x10-7 2 ABCA13,7SK
7 51609116 56336142 54 rs378423353c 53088085 T 0.124 3.06x10-8 83 CYSTM1
7 56661674 56918810 2 rs109970665a 56803371 T 0.202 7.40 x10-6 0
7 57127004 57315768 23 rs43519218a 57167198 A 0.155 9.72 x10-7 3 YIPF5,KCTD16
10 42266891 43301260 21 rs380551392a 42361205 C 0.928 2.07 x10-6 16
10 48984533 49023546 3 rs381355858c 48984533 A 0.056 7.70 x10-7 1 RORA
12 84384983 84384988 2 a 84384988 A 0.979 2.00 x10-6 0
13 59061885 59108749 2 rs135350894d 59108749 A 0.734 8.41 x10-6 2 PMEPA1,ZBP1
14 43501239 48599522 31 rs439739810c 46819750 A 0.959 3.68 x10-7 26 FABP9
14 56445115 56647342 86 rs110601974a 56596172 T 0.034 5.56 x10-6 0
18 55926709 57016965 63 rs383639920c 56551941 G 0.017 5.91 x10-10 60 CPT1C
18 57482287 57591440 43 rs384897226b 57503131 T 0.054 4.84 x10-7 6 KLK14,ENSBTAG00000039212
18 58059492 58193281 10 rs381577268d 58141989 T 0.020 1.97 x10-14 7 ZNF613
19 25993220 26579664 19 rs109632828a 26480940 A 0.644 1.54 x10-6 1 PITPNM3
19 26999418 27517741 7 rs381172322a 27483350 G 0.395 4.67 x10-7 27
19 28459429 28983381 65 rs380899775b 28529700 G 0.136 4.91 x10-8 15 PFAS, SLC25A35,
19 32888891 38468608 46 rs41912302b 35264878 C 0.841 4.61 x10-8 80 RAI1
21 40861557 41148186 32 rs208954540a 40907918 A 0.390 1.38 x10-7 1 ENSBTAG00000027863
24 59171495 59180428 2 rs210181427a 59179570 C 0.625 4.19 x10-6 0
25 13457962 13626389 57 rs384885964c 13478288 A 0.088 8.20 x10-7 1 PARN
25 22121076 22148689 3 rs109616718a 22148423 T 0.230 9.30 x10-7 1 PRKCB
28 9756961 9775184 40 rs208635521a 9774271 A 0.647 2.20 x10-7 0
28 17248068 17249161 2 rs459816768a 17248473 T 0.937 8.52 x10-7 0
28 25271166 25382045 4 rs42142414c 25294572 A 0.614 2.67 x10-7 3 STOX1,DDX50

*BTA, Bos taurus autosome number; SNP, name of single nucleotide polymorphism. No SNP <10-5 is the number of SNPs within the QTL with a p-value ≤ 1 × 10-5. P-value is the p-value of strongest SNP association. + Allele is the allele that had a positive SNP effect on gestation length. No of genes is the number of genes in the QTL. If no gene was present in the QTL the nearest functional candidate gene within 250 kb was chosen. aintergenic, bupstream gene variant, cintronic, ddownstream gene variant, gene in which the most significant SNP within the QTL was identified in.