Table 2.

Summary of General Population Studies on CAC and CVD Risk

Authors	Cohort	Outcome
Detrano et al. 2008	MESA	↑CAC associated with ↑CVD events
Erbel et al. 2010	Heinz Nixdorf Recall Study	↑CAC associated with ↑CVD events
Rana et al. 2012	EISNER study	CAC, not multiple biomarkers, improved CVD risk prediction
Polonsky et al. 2010	MESA	CAC improved CVD risk prediction when added to a traditional risk score
Blaha et al. 2016	MESA	Among negative risk markers, CAC = 0 was the most accurate

MESA, Multi-Ethnic Study of Atherosclerosis; CAC, coronary artery calcium; CVD, cardiovascular disease; EISNER, Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research