Table 2.

Enriched pathways for the 15-gene overlap set.

Pathway Name	Set Size	Candidates Contained	p value	Pathway Source	Pathway Description
1) Dopaminergic Synapse	131	4 (3.1%)a CACNA1C MAOA SCN1A SLC6A3	9.14e-06	KEGG	Dopamine is found in the brain and controls several functions such as locomotor activity, motivation and reward, learning and memory, and endocrine regulation.
2) Serotonergic Synapse	115	4 (3.5%)a CACNA1C HTR2A MAOA SLC6A4	5.08e-6	KEGG	Serotonin is a neurotransmitter that has a key role in physiological functions including sleep, emotion, learning and memory, and pathology.
3) MECP2 and Associated Rett Syndrome	63	4 (6.3%)a BDNF MECP2 RBFOX1 UBE3A	4.84e-07	Wikipathways	MECP2 regulates neuronal function and development. It effects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. MECP2 is also involved in neuronal differentiation, maturation, morphology and function, and influences synaptic plasticity. Mutations in MECP2 are associated with Rett Syndrome, schizophrenia, PPM-X-syndrome, FASD, and ASD.
4) Sudden Infant Death Syndrome and (SIDS) Susceptibility Pathways	159	5 (3.1%)a BDNF HTR2A MAOA MECP2 SLC6A4	4.72e-07	Wikipathways	SIDS is the sudden and unexpected death of an infant, almost always during sleep, where no cause of death can be found by autopsy. Factors that mediate SIDS are likely to be both biological and behavioral, such as sleeping position, environment and stress during a critical phase of infant development. This pathway describes candidate genes associated with neuronal signaling, cardiac contraction, and inflammatory response that are empirically related to SIDS.

Note. To be included in the manuscript, biological pathways had to contain at least 25% of the genes on the overlap list.

^aThese numbers refer to the percentage of each total pathway (set size) represented in our overlap list.