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Dephosphoraylation of peptides corresponding to WT and mutant INSR by the PTP1B phosphatase. (A) The mutation R1152Q occurs in the triple phosphorylation site of INSR and is adjacent to the Y1151 phosphorylation site. (B) SAMDI spectra following treatment of each peptide with PTP1B shows significantly more activity on the peptide corresponding to the mutant.
