. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Transl Res. 2019 Jul 10;214:1–16. doi: 10.1016/j.trsl.2019.07.002

Table 6:

Carrier design features to optimize siRNA delivery

Nanoparticle function	Carrier design	Reference

Endosomal escapability	Addition of polyethylenimine (PEI)	[29], [36], [46], [47]
	Polyarginines (RVG-9R)	[24]
	Peptides (p5RHH)	[34], [96]

Stability and release	Redox potential responsiveness (glutathione)	[26], [50]
	Acidic environment (pH) reponsiveness	[29], [32], [34], [96]

Cell and tissue specific recognition	Folate receptor	[25], [37]
	Monoclonal antibody to cell surface receptors	[44]
	Cell-specific ligands	[45]
	Tissue specific ligands	[48], [99]
	Aptamers	[66]