Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2019 Sep 4;143:441–453. doi: 10.1016/j.freeradbiomed.2019.09.002

Figure 9. ALDH2 CRISPR abolished the anti-oxidative stress and anti-apoptosis effects of INT-777 at 24 h after SAH.

Figure 9.

(A) Representative western blot bands. (B-J) Densitometric quantification of TGR5, cAMP, p-PKCε/PKCε, ALDH2, HO-1, 4-HNE, Bcl-2, Bax, and Cleaved Caspase-3 (CC3) in the ipsilateral hemisphere at 24 h after SAH. Vehicle: 10% dimethyl sulfide. Data was represented as mean ± SD. *P<0.05 vs. Sham group, @P<0.05 vs. SAH+Vehicle group, &P<0.05 vs. SAH+scr CRISPR group; One-way ANOVA, Tukey’s post hoc test, n=6 per group; scr CRISPR, scrambled CRISPR.